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Table 1 List of significantly changed proteins from 2D-DIGE identified by MS (p < 0.05, minimum 1.5-fold change)

From: Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons and the hippocampus of a mouse model of FINCA disease

Spot Protein Description Ratio t-Test
1 VCP Transitional endoplasmic reticulum ATPase − 2.07 0.01
2 ANXA6 Annexin A6 1.85 0.04
3 PLS3 Plastin-3 1.62 0.05
4 SNX6 Sorting nexin-6 1.62 0.02
5 hnRNP C1/C2 Heterogeneous nuclear ribonucleoprotein C1/C2 (isoform C2) 1.54 0.03
6 UBL7 Ubiquitin-like protein 7 1.95 0.04
7 GPD1L Glycerol-3-phosphate dehydrogenase 1-like protein (isoform 1 or 2) 1.54 0.03
8 TIMM29 Mitochondrial import inner membrane translocase subunit Tim29 1.57 0.03
9 UBA1 Ubiquitin-like modifier-activating enzyme 1 (C-terminal fragment) 2.45 0.04
10 PRDX6 Peroxiredoxin-6 1.90 0.01
11 PSMA2 Proteasome subunit α type-2 1.66 0.04
12 FTL1 Ferritin light chain 1 1.77 0.04
13 RBM8A RNA-binding protein 8A (isoform 1) 1.60 0.05
14 FTL1 Ferritin light chain 1 (N-terminal fragment) 2.14 0.02
15 PFDN2 Prefoldin subunit 2 1.68 0.05
16 HIST1H4A Histone H4 1.62 0.03
17 HIST1H4A Histone H4 2.89 0.03
18 DYNLRB1 Dynein light chain roadblock-type 1 1.68 0.04
19 ABRACL Costars family protein ABRACL 1.63 0.04
20 PEA15 Astrocytic phosphoprotein PEA-15 (isoform 1) 2.04 0.04
21 BRK1 Protein BRICK1 1.81 0.03
  1. The ratio indicates the change of the normalized spot volumes in Nhlrc2FINCA/− in comparison to Nhlrc2+/+ NPCs
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Molecular Medicine

ISSN: 1528-3658